SLCtables

SLC15A1

Protein name: PEPT1 Aliases: oligopeptide transporter 1, H+-peptide transporter 1 Substrates: di- and tri-peptides, protons, beta-lactam antibiotics Transport type: Cotransporter / H+ Tissue and cellular expression: small intestine, kidney, pancreas, bile duct, liver Subcellular expression: apical surface of epithelial cells from small intestine and kidney Disease: inflammatory bowel disease (Ser117Asn SNP, colonic upregulation) Locus: 13q32.3 Sequence ID: NP_005064.1, NM_005073.3 Gene ID: 6564 Splice variants: N/D

S15A1_HUMAN (UniProt)

Gene names: SLC15A1, PEPT1
Protein names and data: S15A1_HUMAN, Full=Solute carrier family 15 member 1, Full=Intestinal H(+)/peptide cotransporter;Full=Oligopeptide transporter, small intestine isoform;Full=Peptide transporter 1; Length: 708 a.a., Mass: 78806 Da,
fasta formatted sequence
Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: P46059
NextBio: 25539
OMIM: 600544
Ensembl: ENST00000376503
GeneCard: GC13M098683
PharmGenUCSF: SLC15A1
Guide to Pharmacology: SLC15A1 (984)
SLC15 family of peptide transporters (984)
HGNC: HGNC:10920

Genetic variants

See also Ensembl:ENST00000376503

21 - 21 V -> I. VAR_029321
28 - 28 F -> Y. VAR_029322
117 - 117 S -> N (in dbSNP:rs2297322). VAR_022147 2297322
117 - 117 S -> R (in dbSNP:rs8187821). VAR_029323 8187821
122 - 122 V -> M (in dbSNP:rs8187820). VAR_020456 8187820
419 - 419 G -> A (in dbSNP:rs4646227). VAR_020457 4646227
450 - 450 V -> I (in dbSNP:rs2274828). VAR_022148 2274828
451 - 451 T -> N (in dbSNP:rs8187838). VAR_020458 8187838
459 - 459 R -> C (in dbSNP:rs2274827). VAR_022149 2274827
537 - 537 P -> S (in dbSNP:rs8187830). VAR_029324 8187830