Protein name: PHC (phosphate carrier) Aliases: PTP, PiC Substrates: phosphate Transport type: Cotransporter / phosphate, H+; E / phosphate, OH- Tissue and cellular expression: isoform A: heart, skeletal muscle, diaphragm; isoform B: liver, kidney, brain, thymus, lung, heart, skeletal muscle, diaphragm Subcellular expression: inner mitochondrial membrane Disease: mitochondrial phosphate carrier deficiency Locus: 12q23 Sequence ID: NP_002626.1, NM_002635.3 NP_005879.1, NM_005888.3 NP_998776.1, NM_213611.2 Gene ID: 5250 Splice variants: 3 splice variants


Gene names: SLC25A3, PHC, OK/SW-cl.48
Protein names and data: MPCP_HUMAN, Full=Phosphate carrier protein, mitochondrial, Full=Phosphate transport protein;Short=PTP;Full=Solute carrier family 25 member 3;Flags: Precursor; Length: 362 a.a., Mass: 40095 Da,
fasta formatted sequence

Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+)
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q00325
NextBio: 20278
OMIM: 600370 610773
Ensembl: ENST00000552981
GeneCard: GC12P098593
TCDB: 2.A.29.4.2
PharmGenUCSF: SLC25A3
Guide to Pharmacology: SLC25A3 (1061)
Mitochondrial phosphate transporters (1061)

HGNC: HGNC:10989

Genetic variants

See also Ensembl:ENST00000552981