Protein name: OATP1A2 Aliases: N/D Substrates: bile salts, organic anions and cations Transport type: N/D Tissue and cellular expression: brain (endothelial cells), kidney, intestine, liver (cholangiocytes), eye (ciliary body) Subcellular expression: apical (kidney, intestine), ciliary body (eye) Disease: N/D Locus: 12p12 Sequence ID: NP_066580.1, NM_021094.3 NP_602307.1, NM_134431.3 Gene ID: 6579 Splice variants: 2 splice variants

SO1A2_HUMAN (UniProt)

Gene names: SLCO1A2, OATP, OATP1, OATP1A2, SLC21A3
Protein names and data: SO1A2_HUMAN, Full=Solute carrier organic anion transporter family member 1A2, Full=OATP-A;Full=Organic anion-transporting polypeptide 1;Short=OATP-1;Full=Sodium-independent organic anion transporter;Full=Solute carrier family 21 member 3; Length: 670 a.a., Mass: 74145 Da,
fasta formatted sequence

Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin
Cellular location: Cell membrane; Multi-pass membrane protein

Database cross-references

UniProt: P46721
NextBio: 25595
OMIM: 602883
Ensembl: ENST00000452078
GeneCard: GC12M021191
TCDB: 2.A.60.1.14
Guide to Pharmacology: SLCO1A2 (1219)
SLCO family of organic anion transporting polypeptides (1219)

HGNC: HGNC:10956

Genetic variants

See also Ensembl:ENST00000452078