SLC9B2

Protein name: NHA2 Aliases: NHEDC2 Substrates: Na+, Li+ Transport type: N/D Tissue and cellular expression: Distal convoluted tubules of kidney, osteoclasts, β-cells of endocrine pancreas Subcellular expression: N/D Disease: Essential hypertension, diabetes mellitus (?) [PMID: 27685945] [PMID: 23720317] [PMID: 18000046] Locus: 4q24 Sequence ID: NP_849155.2, Gene ID: 133308 Splice variants: N/D

SL9B2_HUMAN (UniProt)

Gene names: SLC9B2, NHA2, NHEDC2
Protein names and data: SL9B2_HUMAN, Full=Mitochondrial sodium/hydrogen exchanger 9B2, Full=Mitochondrial Na(+)/H(+) exchanger NHA2;Full=Na(+)/H(+) exchanger-like domain-containing protein 2;Short=NHE domain-containing protein 2;Full=Sodium/hydrogen exchanger-like domain-containing protein 2;Full=Solute carrier family 9 subfamily B member 2; Length: 537 a.a., Mass: 57564 Da,
fasta formatted sequence
Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)
Cellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
Tissue specificity: Detected in red blood cells (at protein level)

Database cross-references

UniProt: Q86UD5
NextBio: 83201
OMIM: 611789
Ensembl: ENST00000506288
GeneCard: GC04M103019
TCDB: 2.A.36.8.1
Guide to Pharmacology: SLC9B2 (2575)
SLC9 family of sodium/hydrogen exchangers (2575)
HGNC: HGNC:25143

Genetic variants

See also Ensembl:ENST00000506288