Protein name: NHE8 Aliases: N/D Substrates: Na+, K+, H+ Transport type: Exchanger / Na+ (K+), H+ Tissue and cellular expression: Kidney, intestine Subcellular expression: N/D Disease: N/D Locus: 20q13 Sequence ID: NP_001247420.1, NP_056081.1, NM_015266.1 Gene ID: 23315 Splice variants: N/D

SL9A8_HUMAN (UniProt)

Gene names: SLC9A8, KIAA0939, NHE8
Protein names and data: SL9A8_HUMAN, Full=Sodium/hydrogen exchanger 8, Full=Na(+)/H(+) exchanger 8;Short=NHE-8;Full=Solute carrier family 9 member 8; Length: 581 a.a., Mass: 65422 Da,
fasta formatted sequence

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction
Cellular location: Golgi apparatus membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitous. Strongly expressed in skeletal muscle and kidney

Database cross-references

UniProt: Q9Y2E8
NextBio: 45196
OMIM: 612730
Ensembl: ENST00000417961
GeneCard: GC20P049813
TCDB: 2.A.36.1.9
PharmGenUCSF: SLC9A8
Guide to Pharmacology: SLC9A8 (955)
SLC9 family of sodium/hydrogen exchangers (955)

HGNC: HGNC:20728

Genetic variants

See also Ensembl:ENST00000417961