Protein name: NHE4 Aliases: N/D Substrates: Na+, Li+ (?), H+, NH4+ Transport type: Exchanger / Na+, H+ Tissue and cellular expression: Stomach, kidney medulla, hippocampus, zymogen granule of pancreas, salivary gland Subcellular expression: N/D Disease: N/D Locus: 2q12.1 Sequence ID: NP_001011552.2, NM_001011552.3 Gene ID: 389015 Splice variants: N/D

SL9A4_HUMAN (UniProt)

Gene names: SLC9A4, NHE4
Protein names and data: SL9A4_HUMAN, Full=Sodium/hydrogen exchanger 4, Full=Na(+)/H(+) exchanger 4;Short=NHE-4;Full=Solute carrier family 9 member 4; Length: 798 a.a., Mass: 89814 Da,
fasta formatted sequence

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity)
Cellular location: Apical cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic granule membrane; Multi-pass membrane protein (By similarity). Note=Found in zymogen granule membranes (By similarity)

Database cross-references

UniProt: Q6AI14
NextBio: 102516
OMIM: 600531
Ensembl: ENST00000295269
GeneCard: GC02P102456
PharmGenUCSF: SLC9A4
Guide to Pharmacology: SLC9A4 (951)
SLC9 family of sodium/hydrogen exchangers (951)

HGNC: HGNC:11077

Genetic variants

See also Ensembl:ENST00000295269