Protein name: NHE3 Aliases: N/D Substrates: Na+, Li+, H+, NH4+ Transport type: Exchanger / Na+, H+ Tissue and cellular expression: Small intestine, colon, gallbladder, renal proximal tubule, thick and thin limbs of the loop of Henle, gastric parietal cells, epididymis, ovary, thymus, prostate, medulla oblongata, pons Subcellular expression: N/D Disease: congenital Na diarrhea, sudden infant death syndrome Locus: 5p15.3 Sequence ID: NP_004165.2, NM_004174.2 Gene ID: 6550 Splice variants: N/D

SL9A3_HUMAN (UniProt)

Gene names: SLC9A3, NHE3
Protein names and data: SL9A3_HUMAN, Full=Sodium/hydrogen exchanger 3, Full=Na(+)/H(+) exchanger 3;Short=NHE-3;Full=Solute carrier family 9 member 3; Length: 834 a.a., Mass: 92855 Da,
fasta formatted sequence

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction
Cellular location: Cell membrane; Multi-pass membrane protein. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane

Database cross-references

UniProt: P48764
NextBio: 25493
OMIM: 182307
Ensembl: ENST00000264938
GeneCard: GC05M000473
PharmGenUCSF: SLC9A3
Guide to Pharmacology: SLC9A3 (950)
SLC9 family of sodium/hydrogen exchangers (950)

HGNC: HGNC:11073

Genetic variants

See also Ensembl:ENST00000264938