Protein name: NHE2 Aliases: N/D Substrates: Na+, Li+, H+, NH4+ Transport type: Exchanger / Na+, H+ Tissue and cellular expression: Brush border of small intestine, colon, gallbladder, stomach, endothelial cells, kidney Subcellular expression: N/D Disease: N/D Locus: 2q11.2 Sequence ID: NP_003039.2, NM_003048.3 Gene ID: 6549 Splice variants: N/D

SL9A2_HUMAN (UniProt)

Gene names: SLC9A2, NHE2
Protein names and data: SL9A2_HUMAN, Full=Sodium/hydrogen exchanger 2, Full=Na(+)/H(+) exchanger 2;Short=NHE-2;Full=Solute carrier family 9 member 2; Length: 812 a.a., Mass: 91520 Da,
fasta formatted sequence

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine

Database cross-references

UniProt: Q9UBY0
NextBio: 25489
OMIM: 600530
Ensembl: ENST00000233969
GeneCard: GC02P102694
PharmGenUCSF: SLC9A2
Guide to Pharmacology: SLC9A2 (949)
SLC9 family of sodium/hydrogen exchangers (949)

HGNC: HGNC:11072

Genetic variants

See also Ensembl:ENST00000233969