Protein name: NCX3 Aliases: N/D Substrates: Na+, Ca2+ Transport type: Exchanger / Na+, Ca2+ Tissue and cellular expression: expressed selectively in skeletal muscle, at lower levels in some brain regions Subcellular expression: N/D Disease: N/D Locus: 14q24.1 Sequence ID: NP_001123889.1, NM_001130417.1 NP_150287.1, NM_033262.3 NP_489479.1, NP_891977.1, NM_182932.1 NP_891981.1, NM_182936.1 NP_892114.1, NM_183002.1 Gene ID: 6547 Splice variants: 5 splice variants, exon A splice variants in skeletal muscle, exon B splice variants in skeletal muscle and brain

NAC3_HUMAN (UniProt)

Gene names: SLC8A3, NCX3
Protein names and data: NAC3_HUMAN, Full=Sodium/calcium exchanger 3, Full=Na(+)/Ca(2+)-exchange protein 3;Flags: Precursor; Length: 927 a.a., Mass: 103010 Da,
fasta formatted sequence

Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle

Database cross-references

UniProt: P57103
NextBio: 25473
OMIM: 607991
Ensembl: ENST00000534137
GeneCard: GC14M070044
TCDB: 2.A.19.3.3
PharmGenUCSF: SLC8A3
Guide to Pharmacology: SLC8A3 (947)
SLC8 family of sodium/calcium exchangers (947)

HGNC: HGNC:11070

Genetic variants

See also Ensembl:ENST00000534137