Protein name: LAT2 Aliases: [4F2hc], system L Substrates: neutral L-amino acids, T3, T4, BCH Transport type: Exchanger (similar intra- and extracellular selectivities, lower intracellular apparent affinity) Tissue and cellular expression: small intestine, kidney, lung, heart, spleen, liver, brain, placenta, prostate, ovary, fetal liver, testis, skeletal muscle Subcellular expression: basolateral in epithelial cells Disease: N/D Locus: 14q11.2 Sequence ID: NP_001253965.1, NP_001253966.1, NP_036376.2, NM_012244.2 NP_877392.1, NM_182728.1 Gene ID: 23428 Splice variants: 2 splice variants

LAT2_HUMAN (UniProt)

Gene names: SLC7A8, LAT2
Protein names and data: LAT2_HUMAN, Full=Large neutral amino acids transporter small subunit 2, Full=L-type amino acid transporter 2;Short=hLAT2;Full=Solute carrier family 7 member 8; Length: 535 a.a., Mass: 58382 Da,
fasta formatted sequence

Function: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Cellular location: Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi
Tissue specificity: Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2

Database cross-references

UniProt: Q9UHI5
NextBio: 45663
OMIM: 604235
Ensembl: ENST00000316902
GeneCard: GC14M023125
PharmGenUCSF: SLC7A8
Guide to Pharmacology: SLC7A8 (897)
SLC7 family (897)

HGNC: HGNC:11066

Genetic variants

See also Ensembl:ENST00000316902