Protein name: y+LAT2 Aliases: [4F2hc], system y+L Substrates: cationic amino acids (Na+ indep.), large neutral L-amino acids (Na+ dep.) Transport type: Exchanger (preferentially intracellular cationic amino acid against extracellular neutral amino acid / Na+) Tissue and cellular expression: brain, small intestine, testis, parotids, heart, kidney, lung, thymus Subcellular expression: basolateral in epithelial cells Disease: N/D Locus: 16q22.1 Sequence ID: NP_001070253.1, NM_001076785.2 NP_003974.3, NM_003983.5 Gene ID: 9057 Splice variants: N/D


Gene names: SLC7A6, KIAA0245
Protein names and data: YLAT2_HUMAN, Full=Y+L amino acid transporter 2, Full=Cationic amino acid transporter, y+ system;Full=Solute carrier family 7 member 6;Full=y(+)L-type amino acid transporter 2;Short=Y+LAT2;Short=y+LAT-2; Length: 515 a.a., Mass: 56828 Da,
fasta formatted sequence

Function: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells
Cellular location: Basolateral cell membrane; Multi-pass membrane protein
Tissue specificity: Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines

Database cross-references

UniProt: Q92536
NextBio: 33939
OMIM: 605641
Ensembl: ENST00000566454
GeneCard: GC16P068298
PharmGenUCSF: SLC7A6
Guide to Pharmacology: SLC7A6 (899)
SLC7 family (899)

HGNC: HGNC:11064

Genetic variants

See also Ensembl:ENST00000566454