Protein name: LAT1 Aliases: [4F2hc], 4F2lc, system L Substrates: large neutral L-amino acids, T3, T4, L-DOPA, BCH Transport type: Exchanger (similar intra- and extracellular selectivities, lower intracellular apparent affinity) Tissue and cellular expression: brain, ovary, testis, placenta, spleen, colon, blood-brain barrier, fetal liver, activated lymphocytes, tumor cells Subcellular expression: N/D Disease: cancer Locus: 16q24.3 Sequence ID: NP_003477.4, NM_003486.5 Gene ID: 8140 Splice variants: N/D

LAT1_HUMAN (UniProt)

Gene names: SLC7A5, CD98LC, LAT1, MPE16
Protein names and data: LAT1_HUMAN, Full=Large neutral amino acids transporter small subunit 1, Full=4F2 light chain;Short=4F2 LC;Short=4F2LC;Full=CD98 light chain;Full=Integral membrane protein E16;Full=L-type amino acid transporter 1;Short=hLAT1;Full=Solute carrier family 7 member 5;Full=y+ system cationic amino acid transporter; Length: 507 a.a., Mass: 55010 Da,
fasta formatted sequence

Function: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts
Cellular location: Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity)
Tissue specificity: Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2

Database cross-references

UniProt: Q01650
NextBio: 30811
OMIM: 600182
Ensembl: ENST00000565644
GeneCard: GC16M087830
PharmGenUCSF: SLC7A5
Guide to Pharmacology: SLC7A5 (896)
SLC7 family (896)

HGNC: HGNC:11063

Genetic variants

See also Ensembl:ENST00000565644