Protein name: CAT-3 Aliases: ATRC3, system y+ Substrates: cationic L-amino acids Transport type: Facilitated transporter Tissue and cellular expression: thymus, ovary, testis, brain (neurons) Subcellular expression: N/D Disease: N/D Locus: Xq13.1 Sequence ID: NP_001041629.1, NM_001048164.2 NP_116192.4, NM_032803.5 Gene ID: 84889 Splice variants: 2 splice variants

CTR3_HUMAN (UniProt)

Gene names: SLC7A3, ATRC3, CAT3
Protein names and data: CTR3_HUMAN, Full=Cationic amino acid transporter 3;Short=CAT-3;Short=CAT3, Full=Cationic amino acid transporter y+;Full=Solute carrier family 7 member 3; Length: 619 a.a., Mass: 67169 Da,
fasta formatted sequence

Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala

Database cross-references

UniProt: Q8WY07
NextBio: 75212
OMIM: 300443
Ensembl: ENST00000374299
GeneCard: GC0XM070926
PharmGenUCSF: SLC7A3
Guide to Pharmacology: SLC7A3 (893)
SLC7 family (893)

HGNC: HGNC:11061

Genetic variants

See also Ensembl:ENST00000374299