Protein name: CAT-2 (A or B) Aliases: ATRC2, system y+ Substrates: cationic L-amino acids Transport type: Facilitated transporter Tissue and cellular expression: CAT-2A: liver, skeletal muscle, pancreas, CAT-2B: inducible in many cell types Subcellular expression: N/D Disease: N/D Locus: 8p22 Sequence ID: NP_001008539.3, NM_001008539.3 NP_001158243.1, NM_001164771.1 NP_003037.4, NM_003046.5 Gene ID: 6542 Splice variants: CAT-2A: low affinity, CAT-2B: high affinity

CTR2_HUMAN (UniProt)

Gene names: SLC7A2, ATRC2, CAT2
Protein names and data: CTR2_HUMAN, Full=Low affinity cationic amino acid transporter 2;Short=CAT-2;Short=CAT2, Full=Solute carrier family 7 member 2; Length: 658 a.a., Mass: 71673 Da,
fasta formatted sequence

Function: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart

Database cross-references

UniProt: P52569
NextBio: 25455
OMIM: 601872
Ensembl: ENST00000522656
GeneCard: GC08P017497
PharmGenUCSF: SLC7A2
Guide to Pharmacology: SLC7A2 (892)
SLC7 family (892)

HGNC: HGNC:11060

Genetic variants

See also Ensembl:ENST00000522656