Protein name: CAT-1 Aliases: ATRC1, system y+ Substrates: cationic L-amino acids Transport type: Facilitated transporter (non-obligatory E) Tissue and cellular expression: ubiquitous except for liver, lacrimal gland Subcellular expression: basolateral, intracellular membranes in epithelial cells Disease: N/D Locus: 13q12.3 Sequence ID: NP_003036.1, NM_003045.4 Gene ID: 6541 Splice variants: N/D

CTR1_HUMAN (UniProt)

Gene names: SLC7A1, ATRC1, ERR, REC1L
Protein names and data: CTR1_HUMAN, Full=High affinity cationic amino acid transporter 1;Short=CAT-1;Short=CAT1, Full=Ecotropic retroviral leukemia receptor homolog;Full=Ecotropic retrovirus receptor homolog;Short=ERR;Full=Solute carrier family 7 member 1;Full=System Y+ basic amino acid transporter; Length: 629 a.a., Mass: 67638 Da,
fasta formatted sequence

Function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitous

Database cross-references

UniProt: P30825
NextBio: 25451
OMIM: 104615
Ensembl: ENST00000380752
GeneCard: GC13M029509
PharmGenUCSF: SLC7A1
Guide to Pharmacology: SLC7A1 (891)
SLC7 family (891)

HGNC: HGNC:11057

Genetic variants

See also Ensembl:ENST00000380752