Protein name: N/D Aliases: GlyT2 Substrates: glycine Transport type: N/D Tissue and cellular expression: brain (glycinergic neurons, Golgi cells, brain stem, cerebellum), spinal cord Subcellular expression: N/D Disease: pain, spasticity, hyperekplexia Locus: 11p15.2-15.1 Sequence ID: NP_004202.2, NM_004211.3 Gene ID: 9152 Splice variants: N/D

SC6A5_HUMAN (UniProt)

Gene names: SLC6A5, GLYT2, NET1
Protein names and data: SC6A5_HUMAN, Full=Sodium- and chloride-dependent glycine transporter 2;Short=GlyT-2;Short=GlyT2, Full=Solute carrier family 6 member 5; Length: 797 a.a., Mass: 87434 Da,
fasta formatted sequence

Function: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in medulla, and to a lesser extent in spinal cord and cerebellum

Database cross-references

UniProt: Q9Y345
NextBio: 34335
OMIM: 604159 614618
Ensembl: ENST00000525748
GeneCard: GC11P020599
PharmGenUCSF: SLC6A5
Guide to Pharmacology: SLC6A5 (936)
Glycine transporter subfamily (936)

HGNC: HGNC:11051

Genetic variants

See also Ensembl:ENST00000525748