Protein name: N/D Aliases: 5-HTT, SERT Substrates: serotonin Transport type: N/D Tissue and cellular expression: brain, peripheral nervous system, placenta, epithelium cells, platelets Subcellular expression: extrasynaptic axonal membranes, dendrites (brain) Disease: anxiety, depression, autism gastrointestinal disorders, premature ejaculation, obesity, schizophrenia OCD Locus: 17q11.1-q12 Sequence ID: NP_001036.1, NM_001045.4 Gene ID: 6532 Splice variants: N/D

SC6A4_HUMAN (UniProt)

Gene names: SLC6A4, HTT, SERT
Protein names and data: SC6A4_HUMAN, Full=Sodium-dependent serotonin transporter, Full=5HT transporter;Short=5HTT;Full=Solute carrier family 6 member 4; Length: 630 a.a., Mass: 70325 Da,
fasta formatted sequence

Function: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner
Cellular location: Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin
Tissue specificity: Expressed in platelets (at protein level)

Database cross-references

UniProt: P31645
NextBio: 25415
OMIM: 103780 164230 182138
Ensembl: ENST00000401766
GeneCard: GC17M030194
TCDB: 2.A.22.1.1
PharmGenUCSF: SLC6A4
Guide to Pharmacology: SLC6A4 (928)
Monoamine transporter subfamily (928)

HGNC: HGNC:11050

Genetic variants

Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780]. See also Ensembl:ENST00000401766