Protein name: N/D Aliases: B0AT2, v7-3, NTT7-3 Substrates: large, neutral amino acids Transport type: N/D Tissue and cellular expression: brain (amygdala, putamen, corpus callosum), kidney Subcellular expression: N/D Disease: ND Locus: 12q21.3 Sequence ID: NP_060527.2, NM_018057.6 NP_877499.1, NM_182767.5 Gene ID: 55117 Splice variants: N/D

S6A15_HUMAN (UniProt)

Gene names: SLC6A15, B0AT2, NTT73, SBAT1
Protein names and data: S6A15_HUMAN, Full=Sodium-dependent neutral amino acid transporter B(0)AT2, Full=Sodium- and chloride-dependent neurotransmitter transporter NTT73;Full=Sodium-coupled branched-chain amino-acid transporter 1;Full=Solute carrier family 6 member 15;Full=Transporter v7-3; Length: 730 a.a., Mass: 81836 Da,
fasta formatted sequence

Function: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent
Cellular location: Membrane; Multi-pass membrane protein (Probable)
Tissue specificity: Almost exclusively expressed in the brain

Database cross-references

UniProt: Q9H2J7
NextBio: 58754
OMIM: 607971
Ensembl: ENST00000450363
GeneCard: GC12M084859
PharmGenUCSF: SLC6A15
Guide to Pharmacology: SLC6A15 (940)
Neutral amino acid transporter subfamily (940)

HGNC: HGNC:13621

Genetic variants

See also Ensembl:ENST00000450363