Protein name: N/D Aliases: GAT1 Substrates: GABA Transport type: N/D Tissue and cellular expression: GABAergic neurons in brain (neocortex, hippocampus, cerebellum, basal ganglia, brain stem, olfactory bulb, glia), peripheral nervous system, retina Subcellular expression: N/D Disease: epilepsy, schizophrenia, anxiety, ADHD Locus: 3p25-p24 Sequence ID: NP_003033.3, NM_003042.3 Gene ID: 6529 Splice variants: N/D

SC6A1_HUMAN (UniProt)

Gene names: SLC6A1, GABATR, GABT1, GAT1
Protein names and data: SC6A1_HUMAN, Full=Sodium- and chloride-dependent GABA transporter 1;Short=GAT-1, Full=Solute carrier family 6 member 1; Length: 599 a.a., Mass: 67074 Da,
fasta formatted sequence

Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals
Cellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity)

Database cross-references

UniProt: P30531
NextBio: 25403
OMIM: 137165
Ensembl: ENST00000287766
GeneCard: GC03P011009
TCDB: 2.A.22.3.2
PharmGenUCSF: SLC6A1
Guide to Pharmacology: SLC6A1 (929)
GABA transporter subfamily (929)

HGNC: HGNC:11042

Genetic variants

See also Ensembl:ENST00000287766