Protein name: SMCT1 Aliases: AIT Substrates: short chain fatty acids Transport type: Cotransporter / Na+ Tissue and cellular expression: small intestine, kidney, brain, retina, muscle Subcellular expression: N/D Disease: N/D Locus: 12q23.1 Sequence ID: NP_666018.3, NM_145913.3 Gene ID: 160728 Splice variants: N/D

SC5A8_HUMAN (UniProt)

Gene names: SLC5A8, AIT, SMCT, SMCT1
Protein names and data: SC5A8_HUMAN, Full=Sodium-coupled monocarboxylate transporter 1, Full=Apical iodide transporter;Full=Electrogenic sodium monocarboxylate cotransporter;Full=Sodium iodide-related cotransporter;Full=Solute carrier family 5 member 8; Length: 610 a.a., Mass: 66578 Da,
fasta formatted sequence

Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons
Cellular location: Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells
Tissue specificity: Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors

Database cross-references

UniProt: Q8N695
NextBio: 87983
OMIM: 608044
Ensembl: ENST00000536262
GeneCard: GC12M101155
TCDB: 2.A.21.5.3
PharmGenUCSF: SLC5A8
Guide to Pharmacology: SLC5A8 (922)
Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters (922)

HGNC: HGNC:19119

Genetic variants

See also Ensembl:ENST00000536262