Protein name: NIS Aliases: N/D Substrates: I- (ClO4-, SCN-, NO3-, Br-) Transport type: Cotransporter / Na+, F / Na+, Ch / urea, water Tissue and cellular expression: thyroid, lactating breast, colon, stomach, ovary Subcellular expression: N/D Disease: iodide transport defect (ITD) thyroid hormonogenesis, OMIM 601843 Locus: 19p13.11 Sequence ID: NP_000444.1, NM_000453.2 Gene ID: 6528 Splice variants: N/D

SC5A5_HUMAN (UniProt)

Gene names: SLC5A5, NIS
Protein names and data: SC5A5_HUMAN, Full=Sodium/iodide cotransporter;Short=Na(+)/I(-) cotransporter, Full=Sodium-iodide symporter;Short=Na(+)/I(-) symporter;Full=Solute carrier family 5 member 5; Length: 643 a.a., Mass: 68666 Da,
fasta formatted sequence

Function: Mediates iodide uptake in the thyroid gland
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors

Database cross-references

UniProt: Q92911
NextBio: 25399
OMIM: 274400 601843
Ensembl: ENST00000222248
GeneCard: GC19P018329
TCDB: 2.A.21.5.1
PharmGenUCSF: SLC5A5
Guide to Pharmacology: SLC5A5 (920)
Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters (920)

HGNC: HGNC:11040

Genetic variants

See also Ensembl:ENST00000222248