Protein name: SMIT2 Aliases: SGLT6, KST1 Substrates: myoinositol, chiro-inositol Transport type: Cotransporter / Na+ Tissue and cellular expression: thyroid, brain, heart, muscle, spleen, liver, lung Subcellular expression: N/D Disease: N/D Locus: 16p12.1 Sequence ID: NP_001245340.1, NP_001245341.1, NP_001245342.1, NP_443176.2, NM_052944.2 Gene ID: 115584 Splice variants: splicing eliminates exon 6 and TMH 4


Gene names: SLC5A11, KST1, SLGTX, SMIT2
Protein names and data: SC5AB_HUMAN, Full=Sodium/myo-inositol cotransporter 2;Short=Na(+)/myo-inositol cotransporter 2, Full=Sodium-dependent glucose cotransporter;Full=Sodium/glucose cotransporter KST1;Full=Sodium/myo-inositol transporter 2;Short=SMIT2;Full=Solute carrier family 5 member 11; Length: 675 a.a., Mass: 74036 Da,
fasta formatted sequence

Function: Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney
Cellular location: Membrane; Multi-pass membrane protein (By similarity)
Tissue specificity: Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes

Database cross-references

UniProt: Q8WWX8
NextBio: 79624
OMIM: 610238
Ensembl: ENST00000567758
GeneCard: GC16P024859
TCDB: 2.A.21.3.6
PharmGenUCSF: SLC5A11
Guide to Pharmacology: SLC5A11 (925)
Sodium myo-inositol cotransporter transporters (925)

HGNC: HGNC:23091

Genetic variants

See also Ensembl:ENST00000567758