Protein name: SGLT1 Aliases: None Substrates: glucose and galactose (urea and water) Transport type: Cotransporter / Na+, (H+), F / Na+, (H+), Ch / urea, water Tissue and cellular expression: small intestine, trachea, kidney, heart, brain, testes, prostrate Subcellular expression: N/D Disease: glucose galactose malabsorption, OMIM 182380 Locus: 22q12.3 Sequence ID: NP_000334.1, NM_000343.3 NP_001243243.1, NM_001256314.1 Gene ID: 6523 Splice variants: N/D

SC5A1_HUMAN (UniProt)

Gene names: SLC5A1, NAGT, SGLT1
Protein names and data: SC5A1_HUMAN, Full=Sodium/glucose cotransporter 1;Short=Na(+)/glucose cotransporter 1, Full=High affinity sodium-glucose cotransporter;Full=Solute carrier family 5 member 1; Length: 664 a.a., Mass: 73498 Da,
fasta formatted sequence

Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed mainly in intestine and kidney

Database cross-references

UniProt: P13866
NextBio: 25375
OMIM: 182380 606824
Ensembl: ENST00000266088
GeneCard: GC22P032043
TCDB: 2.A.21.3.1
PharmGenUCSF: SLC5A1
Guide to Pharmacology: SLC5A1 (915)
Hexose transporter family (915)

HGNC: HGNC:11036

Genetic variants

See also Ensembl:ENST00000266088