Protein name: NBCn1 Aliases: NBC2, NBC3, SLC4A6 Substrates: chloride bicarbonate Transport type: Cotransporter Tissue and cellular expression: widely distributed, spleen, testes, brain, heart, lung, liver, kidney; not skeletal muscle Subcellular expression: N/D Disease: blindness, auditory impairment Locus: 3p22 Sequence ID: NP_001245308.1, NP_001245309.1, NP_003606.3, NM_003615.3 Gene ID: 9497 Splice variants: >=3 splice variants

S4A7_HUMAN (UniProt)

Gene names: SLC4A7, BT, NBC2, NBC2B, NBC3, SBC2, SLC4A6
Protein names and data: S4A7_HUMAN, Full=Sodium bicarbonate cotransporter 3, Full=Sodium bicarbonate cotransporter 2;Full=Sodium bicarbonate cotransporter 2b;Short=Bicarbonate transporter;Full=Solute carrier family 4 member 7; Length: 1214 a.a., Mass: 136044 Da,
fasta formatted sequence

Function: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity
Cellular location: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein (By similarity). Cell projection, stereocilium (By similarity). Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity)
Tissue specificity: Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle

Database cross-references

UniProt: Q9Y6M7
NextBio: 35580
OMIM: 603353
Ensembl: ENST00000428386
GeneCard: GC03M027372
PharmGenUCSF: SLC4A7
Guide to Pharmacology: SLC4A7 (910)
Sodium-dependent HCO3- transporters (910)

HGNC: HGNC:11033

Genetic variants

See also Ensembl:ENST00000428386