Protein name: AE3 Aliases: N/D Substrates: chloride bicarbonate Transport type: Exchanger Tissue and cellular expression: brain, retina, heart, smooth muscle, also epithelial cells of kidney, GI tract Subcellular expression: N/D Disease: N/D Locus: 2q36 Sequence ID: NP_005061.2, NM_005070.3 NP_963868.2, NM_201574.2 Gene ID: 6508 Splice variants: >=2 splice variants

B3A3_HUMAN (UniProt)

Gene names: SLC4A3, AE3
Protein names and data: B3A3_HUMAN, Full=Anion exchange protein 3;Short=AE 3;Short=Anion exchanger 3, Full=CAE3/BAE3;Full=Cardiac/brain band 3-like protein;Full=Neuronal band 3-like protein;Full=Solute carrier family 4 member 3; Length: 1232 a.a., Mass: 135791 Da,
fasta formatted sequence

Function: Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Both BAE3 and CAE3 are expressed in failing ventricle

Database cross-references

UniProt: P48751
NextBio: 25305
OMIM: 106195
Ensembl: ENST00000373762
GeneCard: GC02P219627
PharmGenUCSF: SLC4A3
Guide to Pharmacology: SLC4A3 (906)
Anion exchangers (906)

HGNC: HGNC:11029

Genetic variants

See also Ensembl:ENST00000373762