Protein name: HRG-1 Aliases: N/D Substrates: heme Transport type: Cotransporter / H+ ? Tissue and cellular expression: liver, heart, CNS, kidney, skeletal muscle, small intestine Subcellular expression: localizes predominantly to the endosome, also observed on the cell surface when overexpressed Disease: N/D Locus: 12q13.11 Sequence ID: NP_060312.2, NM_017842.2 Gene ID: 55652 Splice variants: two isoforms differ in the length of the 3'-UTR, short form is predominantly expressed

HRG1_HUMAN (UniProt)

Gene names: SLC48A1, HRG1
Protein names and data: HRG1_HUMAN, Full=Heme transporter HRG1, Full=Heme-responsive gene 1 protein homolog;Short=HRG-1;Short=hHRG-1;Full=Solute carrier family 48 member 1; Length: 146 a.a., Mass: 16419 Da,
fasta formatted sequence

Function: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment
Cellular location: Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in the brain, kidney, heart and skeletal muscle. Moderately expressed in the liver, lung, placenta and small intestine

Database cross-references

UniProt: Q6P1K1
NextBio: 60356
OMIM: 612187
Ensembl: ENST00000547002
GeneCard: GC12P047753
Guide to Pharmacology: SLC48A1 (1218)
SLC48 heme transporter (1218)

HGNC: HGNC:26035

Genetic variants

See also Ensembl:ENST00000547002