Protein name: N/D Aliases: MATE2-K (MATE2, MATE2-B) Substrates: TEA, MPP, cimetidine, metformin, guanidine, procainamide Transport type: N/D Tissue and cellular expression: kidney (MATE2-K) Subcellular expression: N/D Disease: N/D Locus: N/D Sequence ID: NP_001093116.1, NM_001099646.1 NP_001243592.1, NM_001256663.1 NP_690872.2, NM_152908.3 Gene ID: 146802 Splice variants: N/D

S47A2_HUMAN (UniProt)

Gene names: SLC47A2, MATE2
Protein names and data: S47A2_HUMAN, Full=Multidrug and toxin extrusion protein 2;Short=MATE-2;Short=hMATE-2, Full=Kidney-specific H(+)/organic cation antiporter;Full=Solute carrier family 47 member 2; Length: 602 a.a., Mass: 65085 Da,
fasta formatted sequence

Function: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes
Cellular location: Cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the brush border membranes of the proximal tubules
Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain

Database cross-references

UniProt: Q86VL8
NextBio: 85455
OMIM: 609833
Ensembl: ENST00000574239
GeneCard: GC17M019678
TCDB: 2.A.66.1.20
PharmGenUCSF: SLC47A2
Guide to Pharmacology: SLC47A2 (1217)
SLC47 family of multidrug and toxin extrusion transporters (1217)

HGNC: HGNC:26439

Genetic variants

See also Ensembl:ENST00000574239