Protein name: ZIP8, BIGM103, LZT-Hs6 Aliases: N/D Substrates: Zn, Cd, Mn Transport type: N/D Tissue and cellular expression: widespread, T-cells, erythroid, testis Subcellular expression: plasma membrane, lysosomes, mitochondria Disease: inflammation, breast cancer Locus: 4q22-q24 Sequence ID: NP_001128618.1, NM_001135146.1 NP_001128619.1, NM_001135147.1 NP_001128620.1, NM_001135148.1 NP_071437.3, NM_022154.5 Gene ID: 64116 Splice variants: N/D

S39A8_HUMAN (UniProt)

Gene names: SLC39A8, BIGM103, ZIP8, PP3105
Protein names and data: S39A8_HUMAN, Full=Zinc transporter ZIP8, Full=BCG-induced integral membrane protein in monocyte clone 103 protein;Full=LIV-1 subfamily of ZIP zinc transporter 6;Short=LZT-Hs6;Full=Solute carrier family 39 member 8;Full=Zrt- and Irt-like protein 8;Short=ZIP-8; Length: 460 a.a., Mass: 49631 Da,
fasta formatted sequence

Function: Acts as a zinc-influx transporter
Cellular location: Membrane; Multi-pass membrane protein (Potential). Note=Associated with the lysosomal/endosomal compartment following transfection
Tissue specificity: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas

Database cross-references

UniProt: Q9C0K1
NextBio: 65988
OMIM: 608732
Ensembl: ENST00000424970
GeneCard: GC04M102252
PharmGenUCSF: SLC39A8
Guide to Pharmacology: SLC39A8 (1187)
SLC39 family of metal ion transporters (1187)

HGNC: HGNC:20862

Genetic variants

See also Ensembl:ENST00000424970