Protein name: ZIP4 Aliases: N/D Substrates: Zn Transport type: N/D Tissue and cellular expression: gastrointestinal tract, kidney hippocampal neurons Subcellular expression: plasma membrane, apical surface of enterocytes, lysosomes Disease: AE, pancreatic cancer, liver cancer Locus: 8q24.3 Sequence ID: NP_060237.2, NM_017767.2 NP_570901.2, NM_130849.2 Gene ID: 55630 Splice variants: N/D

S39A4_HUMAN (UniProt)

Gene names: SLC39A4, ZIP4
Protein names and data: S39A4_HUMAN, Full=Zinc transporter ZIP4, Full=Solute carrier family 39 member 4;Full=Zrt- and Irt-like protein 4;Short=ZIP-4;Flags: Precursor; Length: 647 a.a., Mass: 68392 Da,
fasta formatted sequence

Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability
Tissue specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum

Database cross-references

UniProt: Q6P5W5
NextBio: 60265
OMIM: 201100 607059
Ensembl: ENST00000301305
GeneCard: GC08M144409
TCDB: 2.A.5.4.1
PharmGenUCSF: SLC39A4
Guide to Pharmacology: SLC39A4 (1183)
SLC39 family of metal ion transporters (1183)

HGNC: HGNC:17129

Genetic variants

See also Ensembl:ENST00000301305