Protein name: ZIP14, LZT-Hs4 Aliases: N/D Substrates: Zn, Fe, Mn, Cd Transport type: N/D Tissue and cellular expression: widespread, liver Subcellular expression: plasma membrane Disease: asthma, inflammation, colorectal cancer Locus: 8p21.2 Sequence ID: NP_001121903.1, NM_001128431.2 NP_001128625.1, NM_001135153.1 NP_001128626.1, NM_001135154.1 NP_056174.2, NM_015359.4 Gene ID: 23516 Splice variants: N/D

S39AE_HUMAN (UniProt)

Gene names: SLC39A14, KIAA0062, ZIP14
Protein names and data: S39AE_HUMAN, Full=Zinc transporter ZIP14, Full=LIV-1 subfamily of ZIP zinc transporter 4;Short=LZT-Hs4;Full=Solute carrier family 39 member 14;Full=Zrt- and Irt-like protein 14;Short=ZIP-14;Flags: Precursor; Length: 492 a.a., Mass: 54212 Da,
fasta formatted sequence

Function: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake
Cellular location: Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae
Tissue specificity: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes

Database cross-references

UniProt: Q15043
NextBio: 45953
OMIM: 608736
Ensembl: ENST00000381237
GeneCard: GC08P022280
TCDB: 2.A.5.4.5
PharmGenUCSF: SLC39A14
Guide to Pharmacology: SLC39A14 (1193)
SLC39 family of metal ion transporters (1193)

HGNC: HGNC:20858

Genetic variants

See also Ensembl:ENST00000381237