SLC38A1
Protein name: SNAT1 Aliases: ATA1, NAT2, SAT1 Substrates: Q, A, N, C, H, S Transport type: Cotransporter / Na+ Tissue and cellular expression: brain, retina, heart, placenta, adrenal gland Subcellular expression: N/D Disease: N/D Locus: 12q13.11 Sequence ID: NP_001070952.1, NM_001077484.1 NP_109599.3, NM_030674.3 Gene ID: 81539 Splice variants: N/DS38A1_HUMAN (UniProt)
Gene names: SLC38A1, ATA1, NAT2, SAT1, SNAT1Protein names and data: S38A1_HUMAN, Full=Sodium-coupled neutral amino acid transporter 1, Full=Amino acid transporter A1;Full=N-system amino acid transporter 2;Full=Solute carrier family 38 member 1;Full=System A amino acid transporter 1;Full=System N amino acid transporter 1; Length: 487 a.a., Mass: 54048 Da,
fasta formatted sequence
Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA
Cellular location: Cell membrane; Multi-pass membrane protein. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity)
Tissue specificity: Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis
Database cross-references
UniProt: Q9H2H9NextBio: 71767
OMIM: 608490
Ensembl: ENST00000549049
GeneCard: GC12M046183
PharmGenUCSF: SLC38A1
Guide to Pharmacology: SLC38A1 (1169)
System A-like transporters (1169)
HGNC: HGNC:13447
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