Protein name: HFRC1 Aliases: UGTrel8, Hfrc, SQV7L, MGC117215, MGC142139 Substrates: UDP-N-acetylglucosamine Transport type: N/D Tissue and cellular expression: ubiquitous, high in colon, stomach, lung, leukocytes Subcellular expression: Golgi Disease: N/D Locus: 9q22.32 Sequence ID: NP_008932.2, NM_007001.2 Gene ID: 11046 Splice variants: N/D

S35D2_HUMAN (UniProt)

Gene names: SLC35D2, HFRC, UGTREL8
Protein names and data: S35D2_HUMAN, Full=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, Full=Homolog of Fringe connection protein 1;Short=HFRC1;Full=SQV7-like protein;Short=SQV7L;Full=Solute carrier family 35 member D2;Full=UDP-galactose transporter-related protein 8;Short=UGTrel8; Length: 337 a.a., Mass: 36673 Da,
fasta formatted sequence

Function: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling
Cellular location: Golgi apparatus membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus

Database cross-references

UniProt: Q76EJ3
NextBio: 41980
OMIM: 609182
Ensembl: ENST00000375259
GeneCard: GC09M096313
TCDB: 2.A.7.15.1
PharmGenUCSF: SLC35D2
Guide to Pharmacology: SLC35D2 (1150)
SLC35 family of nucleotide sugar transporters (1150)

HGNC: HGNC:20799

Genetic variants

See also Ensembl:ENST00000375259