Protein name: NaPi-IIc Aliases: N/D Substrates: inorganic phosphate (divalent) Transport type: Cotransporter / Na, HPO42- Tissue and cellular expression: kidney (proximal tubule) Subcellular expression: apical membrane (kidney) Disease: hypophosphatemic rickets with hypercalciuria Locus: 9q34 Sequence ID: NP_001170787.1, NM_001177316.1 NP_001170788.1, NM_001177317.1 NP_543153.1, NM_080877.2 Gene ID: 142680 Splice variants: N/D


Gene names: SLC34A3, NPT2C, NPTIIC
Protein names and data: NPT2C_HUMAN, Full=Sodium-dependent phosphate transport protein 2C;Short=Sodium-phosphate transport protein 2C, Full=Na(+)-dependent phosphate cotransporter 2C;Full=Sodium/inorganic phosphate cotransporter IIC;Full=Sodium/phosphate cotransporter 2C;Short=Na(+)/Pi cotransporter 2C;Short=NaPi-2c;Full=Solute carrier family 34 member 3; Length: 599 a.a., Mass: 63550 Da,
fasta formatted sequence

Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q8N130
NextBio: 84599
OMIM: 241530 609826
Ensembl: ENST00000538474
GeneCard: GC09P137230
TCDB: 2.A.58.1.3
PharmGenUCSF: SLC34A3
Guide to Pharmacology: SLC34A3 (1137)
SLC34 family of sodium phosphate co-transporters (1137)

HGNC: HGNC:20305

Genetic variants

See also Ensembl:ENST00000538474