Protein name: GLUT9 Aliases: GLUTX, URATv1 Substrates: urate (glucose, fructose) Transport type: N/D Tissue and cellular expression: kidney, liver, small intestine, placenta, lung, leucocytes Subcellular expression: N/D Disease: renal hypouricemia Locus: 4p16-15.3 Sequence ID: NP_001001290.1, NM_001001290.1 NP_064425.2, NM_020041.2 Gene ID: 56606 Splice variants: 2 splice variants

GTR9_HUMAN (UniProt)

Gene names: SLC2A9, GLUT9
Protein names and data: GTR9_HUMAN, Full=Solute carrier family 2, facilitated glucose transporter member 9, Full=Glucose transporter type 9;Short=GLUT-9; Length: 540 a.a., Mass: 58702 Da,
fasta formatted sequence

Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level)

Database cross-references

UniProt: Q9NRM0
NextBio: 62053
OMIM: 606142 612076
Ensembl: ENST00000506583
GeneCard: GC04M009772
TCDB: 2.A.1.1.72
PharmGenUCSF: SLC2A9
Guide to Pharmacology: SLC2A9 (882)
Class II transporters (882)

HGNC: HGNC:13446

Genetic variants

Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076]. Excess serum accumulation of uric acid can lead to the development of gout. See also Ensembl:ENST00000506583