Protein name: GLUT8 Aliases: GLUTX1 Substrates: glucose, fructose, galactose Transport type: Facilitated transporter Tissue and cellular expression: testis, brain, adrenal gland, liver, spleen, brown adipose tissue, lung Subcellular expression: intracellular Disease: N/D Locus: 9q33.3 Sequence ID: NP_055395.2, NM_014580.3 Gene ID: 29988 Splice variants: N/D

GTR8_HUMAN (UniProt)

Gene names: SLC2A8, GLUT8, GLUTX1
Protein names and data: GTR8_HUMAN, Full=Solute carrier family 2, facilitated glucose transporter member 8, Full=Glucose transporter type 8;Short=GLUT-8;Full=Glucose transporter type X1; Length: 477 a.a., Mass: 50819 Da,
fasta formatted sequence

Function: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity)
Tissue specificity: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues

Database cross-references

UniProt: Q9NY64
NextBio: 52760
OMIM: 605245
Ensembl: ENST00000373371
GeneCard: GC09P127398
PharmGenUCSF: SLC2A8
Guide to Pharmacology: SLC2A8 (885)
Class II transporters (885)

HGNC: HGNC:13812

Genetic variants

See also Ensembl:ENST00000373371