Protein name: ENT3 Aliases: N/D Substrates: N/D Transport type: unclear, possibly proton-linked Tissue and cellular expression: widely expressed Subcellular expression: intracellular (late endosomal/ lysosomal, mitochondrial membranes) Disease: N/D Locus: 10q22.1 Sequence ID: NP_001167569.1, NM_001174098.1 NP_060814.4, NM_018344.5 Gene ID: 55315 Splice variants: M116R, G427S, G437R and T449R, and various frameshift mutations abolish or reduce transport activity, or cause mistrafficking or protein instability, they are variously associated with H, FHC and PHID syndromes and Rosai-Dorfman disease

S29A3_HUMAN (UniProt)

Gene names: SLC29A3, ENT3, UNQ717/PRO1380
Protein names and data: S29A3_HUMAN, Full=Equilibrative nucleoside transporter 3;Short=hENT3, Full=Solute carrier family 29 member 3; Length: 475 a.a., Mass: 51815 Da,
fasta formatted sequence

Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine
Cellular location: Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface
Tissue specificity: Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart

Database cross-references

UniProt: Q9BZD2
NextBio: 59559
OMIM: 602782 612373
Ensembl: ENST00000373189
GeneCard: GC10P071320
TCDB: 2.A.57.1.6
PharmGenUCSF: SLC29A3
Guide to Pharmacology: SLC29A3 (1119)
SLC29 family (1119)

HGNC: HGNC:23096

Genetic variants

See also Ensembl:ENST00000373189