SLC29A1

Protein name: ENT1 Aliases: N/D Substrates: N/D Transport type: Facilitated transporter Tissue and cellular expression: widely expressed Subcellular expression: primarily in the plasma membrane, but also in nuclear and mitochondrial membranes Disease: N/D Locus: 6p21.1 Sequence ID: NP_001071642.1, NM_001078174.1 NP_001071643.1, NM_001078175.1 NP_001071644.1, NM_001078176.1 NP_001071645.1, NM_001078177.1 NP_004946.1, NM_004955.2 Gene ID: 2030 Splice variants: N/D

S29A1_HUMAN (UniProt)

Gene names: SLC29A1, ENT1
Protein names and data: S29A1_HUMAN, Full=Equilibrative nucleoside transporter 1, Full=Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;Short=Equilibrative NBMPR-sensitive nucleoside transporter;Full=Nucleoside transporter, es-type;Full=Solute carrier family 29 member 1; Length: 456 a.a., Mass: 50219 Da,
fasta formatted sequence
Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)
Cellular location: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells
Tissue specificity: Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen

Database cross-references

UniProt: Q99808
NextBio: 8235
OMIM: 602193
Ensembl: ENST00000427851
GeneCard: GC06P044219
TCDB: 2.A.57.1.1
PharmGenUCSF: SLC29A1
Guide to Pharmacology: SLC29A1 (1117)
SLC29 family (1117)
HGNC: HGNC:11003

Genetic variants

See also Ensembl:ENST00000427851