Protein name: CNT1 Aliases: N/D Substrates: N/D Transport type: concentrative 1:1 sodium:nucleoside Tissue and cellular expression: kidney, liver, small intestine Subcellular expression: primarily plasma membrane-located Disease: N/D Locus: 15q25.3 Sequence ID: NP_004204.3, NM_004213.3 NP_964014.1, NM_201651.1 Gene ID: 9154 Splice variants: S546P, V189I and 1153del

S28A1_HUMAN (UniProt)

Gene names: SLC28A1, CNT1
Protein names and data: S28A1_HUMAN, Full=Sodium/nucleoside cotransporter 1, Full=Concentrative nucleoside transporter 1;Short=CNT 1;Short=hCNT1;Full=Na(+)/nucleoside cotransporter 1;Full=Sodium-coupled nucleoside transporter 1;Full=Solute carrier family 28 member 1; Length: 649 a.a., Mass: 71584 Da,
fasta formatted sequence

Function: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in kidney

Database cross-references

UniProt: O00337
NextBio: 34343
OMIM: 606207
Ensembl: ENST00000394573
GeneCard: GC15P084884
TCDB: 2.A.41.2.3
PharmGenUCSF: SLC28A1
Guide to Pharmacology: SLC28A1 (1114)
SLC28 family (1114)

HGNC: HGNC:11001

Genetic variants

Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity. See also Ensembl:ENST00000394573