SLC27A1

Protein name: FATP1 Aliases: FATP, ACSVL5 Substrates: LCFA, VLCFA Transport type: LCFA transport, VLCFA activation Tissue and cellular expression: BAT, WAT, heart, skeletal muscle, skin, brain, kidney, endothelial cells Subcellular expression: N/D Disease: unknown Locus: 19p13.11 Sequence ID: NP_940982.1, NM_198580.1 Gene ID: 376497 Splice variants: unknown

S27A1_HUMAN (UniProt)

Gene names: SLC27A1, ACSVL5, FATP1
Protein names and data: S27A1_HUMAN, Full=Long-chain fatty acid transport protein 1;Short=FATP-1;Short=Fatty acid transport protein 1;EC=6.2.1.-, Full=Solute carrier family 27 member 1; Length: 646 a.a., Mass: 71108 Da,
fasta formatted sequence
Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity)
Cellular location: Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm (By similarity). Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity)
Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver

Database cross-references

UniProt: Q6PCB7
NextBio: 100645
OMIM: 600691
Ensembl: ENST00000442725
GeneCard: GC19P018292
PharmGenUCSF: SLC27A1
Guide to Pharmacology: SLC27A1 (1108)
SLC27 family of fatty acid transporters (1108)
HGNC: HGNC:10995

Genetic variants

See also Ensembl:ENST00000442725