SLC25A8

Protein name: UCP2 (uncoupling protein 2) Aliases: proton carrier, UCPH Substrates: H+ Transport type: Facilitated transporter Tissue and cellular expression: lung, kidney, spleen, heart Subcellular expression: inner mitochondrial membrane Disease: obesity, type 2 diabetes, congenital hyperinsulinism Locus: 11q13 Sequence ID: NP_003346.2, NM_003355.2 Gene ID: 7351 Splice variants: N/D

UCP2_HUMAN (UniProt)

Gene names: UCP2, SLC25A8
Protein names and data: UCP2_HUMAN, Full=Mitochondrial uncoupling protein 2;Short=UCP 2, Full=Solute carrier family 25 member 8;Full=UCPH; Length: 309 a.a., Mass: 33229 Da,
fasta formatted sequence
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle

Database cross-references

UniProt: P55851
NextBio: 28778
OMIM: 601693 607447
Ensembl: ENST00000310473
GeneCard: GC11M073974
TCDB: 2.A.29.3.4
Guide to Pharmacology: SLC25A8 (1067)
Mitochondrial uncoupling proteins (1067)
HGNC: HGNC:12518

Genetic variants

Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals. See also Ensembl:ENST00000310473