Protein name: UCP1 (uncoupling protein 1) Aliases: thermogenin, proton carrier Substrates: H+ Transport type: Facilitated transporter Tissue and cellular expression: brown adipose tissue Subcellular expression: inner mitochondrial membrane Disease: (obesity) Locus: 4q28-q31 Sequence ID: NP_068605.1, NM_021833.4 Gene ID: 7350 Splice variants: N/D

UCP1_HUMAN (UniProt)

Gene names: UCP1, SLC25A7, UCP
Protein names and data: UCP1_HUMAN, Full=Mitochondrial brown fat uncoupling protein 1;Short=UCP 1, Full=Solute carrier family 25 member 7;Full=Thermogenin; Length: 307 a.a., Mass: 33005 Da,
fasta formatted sequence

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Brown adipose tissue

Database cross-references

UniProt: P25874
NextBio: 28774
OMIM: 113730
Ensembl: ENST00000262999
GeneCard: GC04M140559
TCDB: 2.A.29.3.2
Guide to Pharmacology: SLC25A7 (1066)
Mitochondrial uncoupling proteins (1066)

HGNC: HGNC:12517

Genetic variants

The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus. See also Ensembl:ENST00000262999