Protein name: UCP4 (uncoupling protein 4) Aliases: N/D Substrates: N/D Transport type: Orphan transporter Tissue and cellular expression: brain Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 6p11.2-q12 Sequence ID: NP_004268.3, NM_004277.4 Gene ID: 9481 Splice variants: N/D

UCP4_HUMAN (UniProt)

Gene names: SLC25A27, UCP4, UNQ772/PRO1566
Protein names and data: UCP4_HUMAN, Full=Mitochondrial uncoupling protein 4;Short=UCP 4, Full=Solute carrier family 25 member 27; Length: 323 a.a., Mass: 36064 Da,
fasta formatted sequence

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra

Database cross-references

UniProt: O95847
NextBio: 35536
OMIM: 613725
Ensembl: ENST00000371347
GeneCard: GC06P046620
PharmGenUCSF: SLC25A27
Guide to Pharmacology: SLC25A27 (1069)
Mitochondrial uncoupling proteins (1069)

HGNC: HGNC:21065

Genetic variants

See also Ensembl:ENST00000371347