Protein name: APC1 Aliases: ScaMC-1 Substrates: ATP-Mg2+, ATP, ADP, AMP, Pi Transport type: Exchanger / ATP-Mg, Pi Tissue and cellular expression: testis Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 1p13.3 Sequence ID: NP_037518.3, NM_013386.3 NP_998816.1, NM_213651.1 Gene ID: 29957 Splice variants: 2 splice variants


Gene names: SLC25A24, APC1, MCSC1, SCAMC1
Protein names and data: SCMC1_HUMAN, Full=Calcium-binding mitochondrial carrier protein SCaMC-1, Full=Mitochondrial ATP-Mg/Pi carrier protein 1;Full=Mitochondrial Ca(2+)-dependent solute carrier protein 1;Full=Small calcium-binding mitochondrial carrier protein 1;Full=Solute carrier family 25 member 24; Length: 477 a.a., Mass: 53354 Da,
fasta formatted sequence

Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart

Database cross-references

UniProt: Q6NUK1
NextBio: 52669
OMIM: 608744
Ensembl: ENST00000565488
GeneCard: GC01M108134
PharmGenUCSF: SLC25A24
Guide to Pharmacology: SLC25A24 (1077)
Mitochondrial nucleotide transporter subfamily (1077)

HGNC: HGNC:20662

Genetic variants

See also Ensembl:ENST00000565488