SLC25A2

Protein name: ORC2 (ornithine carrier 2) Aliases: ORNT2 Substrates: ornithine, citrulline, lysine, arginine, histidine Transport type: Exchanger / ornithine, citrulline, H+; ornithine, H+ Tissue and cellular expression: liver, testis, spleen, lung, pancreas, small intestine, brain, kidney Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 5q31 Sequence ID: NP_114153.1, NM_031947.2 Gene ID: 83884 Splice variants: N/D

ORNT2_HUMAN (UniProt)

Gene names: SLC25A2, ORNT2
Protein names and data: ORNT2_HUMAN, Full=Mitochondrial ornithine transporter 2, Full=Solute carrier family 25 member 2; Length: 301 a.a., Mass: 32580 Da,
fasta formatted sequence
Function: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Expressed in liver, kidney, pancreas and cultured fibroblasts

Database cross-references

UniProt: Q9BXI2
NextBio: 72953
OMIM: 608157
Ensembl: ENST00000239451
GeneCard: GC05M141302
TCDB: 2.A.29.19.1
PharmGenUCSF: SLC25A2
Guide to Pharmacology: SLC25A2 (1059)
Mitochondrial amino acid transporter subfamily (1059)
HGNC: HGNC:22921

Genetic variants

Variant Cys-159 has a reduced ornithine transport activity, while variant Gly-181 has an increased activity. See also Ensembl:ENST00000239451