Protein name: OGC (oxoglutarate carrier) Aliases: oxoglutarate / malate carrier, SLC20A4 Substrates: 2-oxoglutarate, malate Transport type: Exchanger / oxoglutarate, malate Tissue and cellular expression: heart, skeletal muscle, liver, kidney, brain, pancreas Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 17p13.3 Sequence ID: NP_003553.2, NM_003562.4 Gene ID: 8402 Splice variants: N/D

M2OM_HUMAN (UniProt)

Gene names: SLC25A11, SLC20A4
Protein names and data: M2OM_HUMAN, Full=Mitochondrial 2-oxoglutarate/malate carrier protein;Short=OGCP, Full=Solute carrier family 25 member 11; Length: 314 a.a., Mass: 34062 Da,
fasta formatted sequence

Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q02978
NextBio: 31442
OMIM: 604165
Ensembl: ENST00000225665
GeneCard: GC17M004937
PharmGenUCSF: SLC25A11
Guide to Pharmacology: SLC25A11 (1053)
Mitochondrial di- and tri-carboxylic acid transporter subfamily (1053)

HGNC: HGNC:10981

Genetic variants

See also Ensembl:ENST00000225665