Protein name: CIC (citrate carrier) Aliases: CTP, tricarboxylate carrier, SLC20A3 Substrates: citrate, isocitrate, malate, PEP Transport type: Exchanger / citrate-H+, malate Tissue and cellular expression: liver, kidney, pancreas, also in brain, lung, heart Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 22q11.21 Sequence ID: NP_005975.1, NM_005984.3 Gene ID: 6576 Splice variants: N/D


Gene names: SLC25A1, SLC20A3
Protein names and data: TXTP_HUMAN, Full=Tricarboxylate transport protein, mitochondrial, Full=Citrate transport protein;Short=CTP;Full=Solute carrier family 25 member 1;Full=Tricarboxylate carrier protein;Flags: Precursor; Length: 311 a.a., Mass: 34013 Da,
fasta formatted sequence

Function: Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Database cross-references

UniProt: P53007
NextBio: 25587
OMIM: 190315
Ensembl: ENST00000215882
GeneCard: GC22M019163
TCDB: 2.A.29.7.2
PharmGenUCSF: SLC25A1
Guide to Pharmacology: SLC25A1 (1051)
Mitochondrial di- and tri-carboxylic acid transporter subfamily (1051)

HGNC: HGNC:10979

Genetic variants

See also Ensembl:ENST00000215882