Protein name: SVCT1 Aliases: YSPL3, NCBT2, MGC22361 Substrates: L-ascorbic acid Transport type: Cotransporter / Na+ Tissue and cellular expression: epithelial tissues including kidney, intestines, liver, lung, skin Subcellular expression: N/D Disease: N/D Locus: 5q31.2-q31.3 Sequence ID: NP_005838.3, NM_005847.4 NP_689898.2, NM_152685.3 Gene ID: 9963 Splice variants: variant 2 uses an in-frame alternative donor splice site at one of the internal coding exons compared to variant 1, resulting in an isoform b with 4 additional aa compared to isoform a

S23A1_HUMAN (UniProt)

Gene names: SLC23A1, SVCT1, YSPL3
Protein names and data: S23A1_HUMAN, Full=Solute carrier family 23 member 1, Full=Na(+)/L-ascorbic acid transporter 1;Full=Sodium-dependent vitamin C transporter 1;Short=hSVCT1;Full=Yolk sac permease-like molecule 3; Length: 598 a.a., Mass: 64831 Da,
fasta formatted sequence

Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus

Database cross-references

UniProt: Q9UHI7
NextBio: 37598
OMIM: 603790
Ensembl: ENST00000353963
GeneCard: GC05M139377
PharmGenUCSF: SLC23A1
Guide to Pharmacology: SLC23A1 (1041)
SLC23 family of ascorbic acid transporters (1041)

HGNC: HGNC:10974

Genetic variants

See also Ensembl:ENST00000353963