SLC22A7

Protein name: OAT2 Aliases: NLT Substrates: organic anions Transport type: Facilitated transporter or E Tissue and cellular expression: liver, kidney Subcellular expression: sinusoidal membrane of hepatocytes (liver), basolateral membrane of proximal tubules (kidney) Disease: N/D Locus: 6q21.2-p-21.1 Sequence ID: NP_006663.2, NM_006672.3 NP_696961.2, NM_153320.2 Gene ID: 10864 Splice variants: kidney- and liver-specific splice variants with no uptake in vitro

S22A7_HUMAN (UniProt)

Gene names: SLC22A7, NLT, OAT2
Protein names and data: S22A7_HUMAN, Full=Solute carrier family 22 member 7, Full=Novel liver transporter;Full=Organic anion transporter 2;Short=hOAT2; Length: 548 a.a., Mass: 60026 Da,
fasta formatted sequence
Function: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate
Cellular location: Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule
Tissue specificity: Expressed in liver and kidney

Database cross-references

UniProt: Q9Y694
NextBio: 41247
OMIM: 604995
Ensembl: ENST00000436107
GeneCard: GC06P043298
PharmGenUCSF: SLC22A7
Guide to Pharmacology: SLC22A7 (1026)
Organic anion transporters (OATs) (1026)
HGNC: HGNC:10971

Genetic variants

See also Ensembl:ENST00000436107