Protein name: OAT1 Aliases: PAHT, NKT Substrates: organic anions Transport type: Exchanger / organic anions Tissue and cellular expression: kidney, placenta, brain Subcellular expression: basolateral membrane of proximal tubules (kidney) Disease: N/D Locus: 11q13.1- q13.2 Sequence ID: NP_004781.2, NM_004790.4 NP_695008.1, NM_153276.2 NP_695009.1, NM_153277.2 NP_695010.1, NM_153278.2 Gene ID: 9356 Splice variants: OAT1-1 from kidney with uptake in vitro, two further variants with no uptake in vitro

S22A6_HUMAN (UniProt)

Gene names: SLC22A6, OAT1, PAHT
Protein names and data: S22A6_HUMAN, Full=Solute carrier family 22 member 6, Full=Organic anion transporter 1;Short=hOAT1;Full=PAH transporter;Short=hPAHT;Full=Renal organic anion transporter 1;Short=hROAT1; Length: 563 a.a., Mass: 61816 Da,
fasta formatted sequence

Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate
Cellular location: Cell membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule

Database cross-references

UniProt: Q4U2R8
NextBio: 35037
OMIM: 607582
Ensembl: ENST00000458333
GeneCard: GC11M062994
PharmGenUCSF: SLC22A6
Guide to Pharmacology: SLC22A6 (1025)
Organic anion transporters (OATs) (1025)

HGNC: HGNC:10970

Genetic variants

See also Ensembl:ENST00000458333