Protein name: OCT2 Aliases: EMT (uptake-2 system) Substrates: organic cations Transport type: Facilitated transporter Tissue and cellular expression: heart, skeletal muscle, brain (neurons, glial cells, plexus choroideus), small intestine, liver, lung, kidney, urinary bladder, mammary gland, skin blood vessels Subcellular expression: N/D Disease: Prostate cancer, coronary heart disease, obsessive compulsive disorder Locus: 6q26-q27 Sequence ID: NP_068812.1, NM_021977.2 Gene ID: 6581 Splice variants: N/D

S22A3_HUMAN (UniProt)

Gene names: SLC22A3, EMTH, OCT3
Protein names and data: S22A3_HUMAN, Full=Solute carrier family 22 member 3, Full=Extraneuronal monoamine transporter;Short=EMT;Full=Organic cation transporter 3; Length: 556 a.a., Mass: 61280 Da,
fasta formatted sequence

Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen

Database cross-references

UniProt: O75751
NextBio: 25609
OMIM: 604842
Ensembl: ENST00000275300
GeneCard: GC06P160348
PharmGenUCSF: SLC22A3
Guide to Pharmacology: SLC22A3 (1021)
Organic cation transporters (OCT) (1021)

HGNC: HGNC:10967

Genetic variants

See also Ensembl:ENST00000275300